Personalized Medicine Through GPCR Pharmacogenomics

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Understanding the magnitude of response to a given treatment at an individual level is one of the most important and long-standing challenges in personalized medicine and pharmacogenomics. A great deal of effort has been placed on understanding variation in drug transport and metabolism. However, little is known about how variability in receptor drug targets affects treatment regimens. G protein-coupled receptors (GPCRs) are the single most prevalent drug target family. Elucidating the spectrum and impact of how a GPCR variant influences ligand binding, signaling and, ultimately, therapeutic effect is vital and could serve as the next important step for understanding variability in drug response.
Original languageEnglish
Title of host publicationPersonalized Medicine Through GPCR Pharmacogenomics
EditorsTerry Kenakin
PublisherElsevier
Publication date1 Aug 2021
DOIs
Publication statusPublished - 1 Aug 2021

ID: 279288718