TY - JOUR

T1 - Moderate consumption of beer (with and without ethanol) and menopausal symptoms: Results from a parallel clinical trial in postmenopausal women

AU - Trius-Soler, Marta

AU - Marhuenda-Muñoz, María

AU - Laveriano-Santos, Emily P

AU - Martínez-Huélamo, Miriam

AU - Sasot, Gemma

AU - Storniolo, Carolina E

AU - Estruch, Ramon

AU - Lamuela-Raventós, Rosa M

AU - Tresserra-Rimbau, Anna

N1 - (Ekstern)

PY - 2021

Y1 - 2021

N2 - The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women.

AB - The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women.

KW - Faculty of Science

KW - Phytoestrogens

KW - Prenylflavonoids

KW - Polyphenols

KW - Health

KW - Menopause

KW - Alcohol

KW - Cardiovascular risk factors

UR - https://doi.org/10.3390/nu13072278

U2 - 10.3390/nu13072278

DO - 10.3390/nu13072278

M3 - Journal article

C2 - 34209273

JO - Nutrients

JF - Nutrients

SN - 2072-6643

M1 - 2278

ER -