TY - JOUR

T1 - Moderate alcohol consumption and lipoprotein subfractions: A systematic review of intervention and observational studies

AU - Wilkens, Trine

AU - Tranæs, Kaare

AU - Eriksen, Jane Nygaard

AU - Dragsted, Lars Ove

N1 - CURIS 2022 NEXS 010

PY - 2022

Y1 - 2022

N2 - Context: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. Objective: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. Data sources: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. Data extraction: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. Results: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B–containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies.Conclusions: Up to 60 g/d alcohol can cause changes in lipoprotein subfractionsand related mechanisms that could influence cardiovascular health.Systematic Review Registration: PROSPERO registration no. 98955

AB - Context: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. Objective: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. Data sources: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. Data extraction: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. Results: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B–containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies.Conclusions: Up to 60 g/d alcohol can cause changes in lipoprotein subfractionsand related mechanisms that could influence cardiovascular health.Systematic Review Registration: PROSPERO registration no. 98955

KW - Faculty of Science

KW - apoB-containing lipoproteins

KW - Cardiovascular disease

KW - Cholesterol efflux capacity

KW - High-density lipoprotein cholesterol

KW - paraoxonase

U2 - 10.1093/nutrit/nuab102

DO - 10.1093/nutrit/nuab102

M3 - Review

C2 - 34957513

VL - 80

SP - 1311

EP - 1339

JO - Nutrition Reviews

JF - Nutrition Reviews

SN - 0029-6643

IS - 5

ER -