Iron concentration in breast milk normalised within one week of a single high-dose infusion of iron isomaltoside in randomised controlled trial
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Iron concentration in breast milk normalised within one week of a single high-dose infusion of iron isomaltoside in randomised controlled trial. / Holm, Charlotte; Thomsen, Lars Lykke; Nørgaard, Astrid; Markova, Veronika; Michaelsen, Kim F.; Langhoff-Roos, Jens.
In: Acta Paediatrica, Vol. 106, No. 2, 2017, p. 256-260.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Iron concentration in breast milk normalised within one week of a single high-dose infusion of iron isomaltoside in randomised controlled trial
AU - Holm, Charlotte
AU - Thomsen, Lars Lykke
AU - Nørgaard, Astrid
AU - Markova, Veronika
AU - Michaelsen, Kim F.
AU - Langhoff-Roos, Jens
N1 - CURIS 2017 NEXS 019
PY - 2017
Y1 - 2017
N2 - AIM: We compared the iron concentration in breast milk after a single high-dose of intravenous iron isomaltoside or daily oral iron for postpartum haemorrhage.METHODS: In this randomised controlled trial, the women were allocated a single dose of intravenous 1,200mg iron isomaltoside or oral iron at a mean daily dose of 70.5mg. We included 65 women with sufficient breast milk three days after inclusion - 30 from the intravenous iron group and 35 from the oral iron group - and collected breast milk and maternal blood samples three days and one week after allocation.RESULTS: The mean (± standard deviation) iron concentration in breast milk in the intravenous and oral groups were 0.72 ± 0.27 mg/L and 0.40 ± 0.18 mg/L at three days (p < 0.001) and 0.47 ± 0.17 mg/L and 0.44 ± 0.25 mg/L after one week (p=0.64). Baseline samples were not available that soon after birth.CONCLUSION: A single high-dose of intravenous iron isomaltoside for postpartum haemorrhage led to a transient increase in the iron concentration in breast milk three days after treatment compared with oral iron. The difference disappeared one week after treatment and mean iron concentrations were within the normal range in all samples. This article is protected by copyright. All rights reserved.
AB - AIM: We compared the iron concentration in breast milk after a single high-dose of intravenous iron isomaltoside or daily oral iron for postpartum haemorrhage.METHODS: In this randomised controlled trial, the women were allocated a single dose of intravenous 1,200mg iron isomaltoside or oral iron at a mean daily dose of 70.5mg. We included 65 women with sufficient breast milk three days after inclusion - 30 from the intravenous iron group and 35 from the oral iron group - and collected breast milk and maternal blood samples three days and one week after allocation.RESULTS: The mean (± standard deviation) iron concentration in breast milk in the intravenous and oral groups were 0.72 ± 0.27 mg/L and 0.40 ± 0.18 mg/L at three days (p < 0.001) and 0.47 ± 0.17 mg/L and 0.44 ± 0.25 mg/L after one week (p=0.64). Baseline samples were not available that soon after birth.CONCLUSION: A single high-dose of intravenous iron isomaltoside for postpartum haemorrhage led to a transient increase in the iron concentration in breast milk three days after treatment compared with oral iron. The difference disappeared one week after treatment and mean iron concentrations were within the normal range in all samples. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Breast milk composition
KW - Intravenous iron isomaltoside
KW - Lactation
KW - Oral iron
KW - Postpartum haemorrhage
U2 - 10.1111/apa.13681
DO - 10.1111/apa.13681
M3 - Journal article
C2 - 27883237
VL - 106
SP - 256
EP - 260
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 2
ER -
ID: 169376948