Cross-species comparison of pregnancy-induced GDF15
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Cross-species comparison of pregnancy-induced GDF15. / Klein, Anders Bue; Ranea-Robles, Pablo; Nicolaisen, Trine Sand; Gil, Cláudia; Johann, Kornelia; Quesada, Julia Prats; Pistoljevic, Nina; Hviid, Kathrine V R; Olsen, Line F; Offersen, Simone Margaard; Helge, Jørn Wulff; Svarre-Nielsen, Henriette; Bakker, Jaco; Kleinert, Maximilian; Clemmensen, Christoffer.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 325, No. 4, 2023, p. E303-E309.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cross-species comparison of pregnancy-induced GDF15
AU - Klein, Anders Bue
AU - Ranea-Robles, Pablo
AU - Nicolaisen, Trine Sand
AU - Gil, Cláudia
AU - Johann, Kornelia
AU - Quesada, Julia Prats
AU - Pistoljevic, Nina
AU - Hviid, Kathrine V R
AU - Olsen, Line F
AU - Offersen, Simone Margaard
AU - Helge, Jørn Wulff
AU - Svarre-Nielsen, Henriette
AU - Bakker, Jaco
AU - Kleinert, Maximilian
AU - Clemmensen, Christoffer
N1 - Afventer publicering som [Epub ahead of print] samt tildeling af CURIS-nummer.
PY - 2023
Y1 - 2023
N2 - Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Although the exact physiological function of GDF15 is not yet fully comprehended, the significant elevation of circulating GDF15 levels during gestation suggests a potential role for this hormone in pregnancy. This is corroborated by genetic association studies in which GDF15 and the GDF15 receptor, GDNF Family Receptor Alpha Like (GFRAL) have been linked to morning sickness and hyperemesis gravidarum (HG) in humans. Here, we studied GDF15 biology during pregnancy in mice, rats, macaques, and humans. In contrast to macaques and humans, mice and rats exhibited an underwhelming induction in plasma GDF15 levels in response to pregnancy (~75-fold increase in macaques vs. ~2-fold increase in rodents). The changes in circulating GDF15 levels were corroborated by the magnitude of Gdf15 mRNA and GDF15 protein expression in placentae from mice, rats, and macaques. These species-specific findings may help guide future studies focusing on GDF15 in pregnancy and on the evaluation of pharmacological strategies to interfere with GDF15-GFRAL signaling to treat severe nausea and HG.
AB - Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Although the exact physiological function of GDF15 is not yet fully comprehended, the significant elevation of circulating GDF15 levels during gestation suggests a potential role for this hormone in pregnancy. This is corroborated by genetic association studies in which GDF15 and the GDF15 receptor, GDNF Family Receptor Alpha Like (GFRAL) have been linked to morning sickness and hyperemesis gravidarum (HG) in humans. Here, we studied GDF15 biology during pregnancy in mice, rats, macaques, and humans. In contrast to macaques and humans, mice and rats exhibited an underwhelming induction in plasma GDF15 levels in response to pregnancy (~75-fold increase in macaques vs. ~2-fold increase in rodents). The changes in circulating GDF15 levels were corroborated by the magnitude of Gdf15 mRNA and GDF15 protein expression in placentae from mice, rats, and macaques. These species-specific findings may help guide future studies focusing on GDF15 in pregnancy and on the evaluation of pharmacological strategies to interfere with GDF15-GFRAL signaling to treat severe nausea and HG.
KW - Faculty of Science
KW - GDF15
KW - GFRAL
KW - Emesis
KW - Nausea
KW - Pregnancy
KW - Placenta
KW - Primates
KW - Macaques
U2 - 10.1152/ajpendo.00134.2023
DO - 10.1152/ajpendo.00134.2023
M3 - Journal article
C2 - 37584611
VL - 325
SP - E303-E309
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 4
ER -
ID: 362792995