Tendon blood flow, angiogenesis, and tendinopathy pathogenesis

Research output: Contribution to journalReviewpeer-review

Standard

Tendon blood flow, angiogenesis, and tendinopathy pathogenesis. / Merkel, Max Flemming Ravn; Hellsten, Ylva; Magnusson, Stig Peter; Kjær, Michael.

In: Translational Sports Medicine, Vol. 4, No. 6, 2021, p. 756-771.

Research output: Contribution to journalReviewpeer-review

Harvard

Merkel, MFR, Hellsten, Y, Magnusson, SP & Kjær, M 2021, 'Tendon blood flow, angiogenesis, and tendinopathy pathogenesis', Translational Sports Medicine, vol. 4, no. 6, pp. 756-771. https://doi.org/10.1002/tsm2.280

APA

Merkel, M. F. R., Hellsten, Y., Magnusson, S. P., & Kjær, M. (2021). Tendon blood flow, angiogenesis, and tendinopathy pathogenesis. Translational Sports Medicine, 4(6), 756-771. https://doi.org/10.1002/tsm2.280

Vancouver

Merkel MFR, Hellsten Y, Magnusson SP, Kjær M. Tendon blood flow, angiogenesis, and tendinopathy pathogenesis. Translational Sports Medicine. 2021;4(6):756-771. https://doi.org/10.1002/tsm2.280

Author

Merkel, Max Flemming Ravn ; Hellsten, Ylva ; Magnusson, Stig Peter ; Kjær, Michael. / Tendon blood flow, angiogenesis, and tendinopathy pathogenesis. In: Translational Sports Medicine. 2021 ; Vol. 4, No. 6. pp. 756-771.

Bibtex

@article{5b2e711c1fa44e9cb6bc04b3b254ddbb,
title = "Tendon blood flow, angiogenesis, and tendinopathy pathogenesis",
abstract = "Physical exercise results in a duration and intensity-dependent vascular response in healthy human tendon. In overused (tendinopathy) and damagedtendon, angiogenic pathways are activated and neovascularization is observed.Whereas no direct relationship exists between the amount of neovessels and degree of tendinopathy symptoms, almost all tendinopathic patients have elevated neovascularization and tendon blood flow, as assessed by Doppler ultrasound methodology. The enhanced flow in tendinopathy can be successfully abolished by heavy resistance training. Already in the early time-phase of tendinopathy (<3 months), neovascularization in the tendon exists but the causal sequence of vascular, metabolic, nociceptive, and matrix tissue changes in tendon pathology is not fully understood. Nevertheless, existing evidences point at neovascularization being an important component of pathogenesis and may occur already before the development of clinical symptoms in tendinopathy.",
keywords = "Faculty of Science, Angiogenesis, Blood flow, Neovascularization, Overuse, Tendinopathy, Tendon",
author = "Merkel, {Max Flemming Ravn} and Ylva Hellsten and Magnusson, {Stig Peter} and Michael Kj{\ae}r",
note = "CURIS 2021 NEXS 301",
year = "2021",
doi = "10.1002/tsm2.280",
language = "English",
volume = "4",
pages = "756--771",
journal = "Translational Sports Medicine",
issn = "2573-8488",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - Tendon blood flow, angiogenesis, and tendinopathy pathogenesis

AU - Merkel, Max Flemming Ravn

AU - Hellsten, Ylva

AU - Magnusson, Stig Peter

AU - Kjær, Michael

N1 - CURIS 2021 NEXS 301

PY - 2021

Y1 - 2021

N2 - Physical exercise results in a duration and intensity-dependent vascular response in healthy human tendon. In overused (tendinopathy) and damagedtendon, angiogenic pathways are activated and neovascularization is observed.Whereas no direct relationship exists between the amount of neovessels and degree of tendinopathy symptoms, almost all tendinopathic patients have elevated neovascularization and tendon blood flow, as assessed by Doppler ultrasound methodology. The enhanced flow in tendinopathy can be successfully abolished by heavy resistance training. Already in the early time-phase of tendinopathy (<3 months), neovascularization in the tendon exists but the causal sequence of vascular, metabolic, nociceptive, and matrix tissue changes in tendon pathology is not fully understood. Nevertheless, existing evidences point at neovascularization being an important component of pathogenesis and may occur already before the development of clinical symptoms in tendinopathy.

AB - Physical exercise results in a duration and intensity-dependent vascular response in healthy human tendon. In overused (tendinopathy) and damagedtendon, angiogenic pathways are activated and neovascularization is observed.Whereas no direct relationship exists between the amount of neovessels and degree of tendinopathy symptoms, almost all tendinopathic patients have elevated neovascularization and tendon blood flow, as assessed by Doppler ultrasound methodology. The enhanced flow in tendinopathy can be successfully abolished by heavy resistance training. Already in the early time-phase of tendinopathy (<3 months), neovascularization in the tendon exists but the causal sequence of vascular, metabolic, nociceptive, and matrix tissue changes in tendon pathology is not fully understood. Nevertheless, existing evidences point at neovascularization being an important component of pathogenesis and may occur already before the development of clinical symptoms in tendinopathy.

KW - Faculty of Science

KW - Angiogenesis

KW - Blood flow

KW - Neovascularization

KW - Overuse

KW - Tendinopathy

KW - Tendon

U2 - 10.1002/tsm2.280

DO - 10.1002/tsm2.280

M3 - Review

VL - 4

SP - 756

EP - 771

JO - Translational Sports Medicine

JF - Translational Sports Medicine

SN - 2573-8488

IS - 6

ER -

ID: 280607714