Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise

Research output: Contribution to journalJournal articlepeer-review

Standard

Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise. / Onslev, Johan; Thomassen, Martin; Wojtaszewski, Jørgen; Bangsbo, Jens; Hostrup, Morten.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 107, No. 3, 2022, p. e1193-e1203.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Onslev, J, Thomassen, M, Wojtaszewski, J, Bangsbo, J & Hostrup, M 2022, 'Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise', Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 3, pp. e1193-e1203. https://doi.org/10.1210/clinem/dgab752

APA

Onslev, J., Thomassen, M., Wojtaszewski, J., Bangsbo, J., & Hostrup, M. (2022). Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise. Journal of Clinical Endocrinology and Metabolism, 107(3), e1193-e1203. https://doi.org/10.1210/clinem/dgab752

Vancouver

Onslev J, Thomassen M, Wojtaszewski J, Bangsbo J, Hostrup M. Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise. Journal of Clinical Endocrinology and Metabolism. 2022;107(3):e1193-e1203. https://doi.org/10.1210/clinem/dgab752

Author

Onslev, Johan ; Thomassen, Martin ; Wojtaszewski, Jørgen ; Bangsbo, Jens ; Hostrup, Morten. / Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise. In: Journal of Clinical Endocrinology and Metabolism. 2022 ; Vol. 107, No. 3. pp. e1193-e1203.

Bibtex

@article{e4618a809a524af2acd005643e34475f,
title = "Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise",
abstract = "Content: Exercise blunts the effect of beta2-agonist on peripheral glucose uptake and energy expenditure. Whether such attenuation extends into recovery is unknown.Objective: To examine the effect of beta2-agonist on leg glucose uptake and metabolic rate in recovery from exercise.Design: Using leg arteriovenous balance technique and analyses of thigh muscle biopsies, we investigated the effect of beta2-agonist (24 mg oral salbutamol) vs placebo on leg glucose, lactate, and oxygen exchange before, during, and 0.5-5-h in recovery from quadriceps exercise, as well as on muscle glycogen resynthesis and activity in recovery. Twelve healthy, lean young men participated.Results: Before exercise, leg glucose uptake was 0.42±0.12 and 0.20±0.02 mmol×min-1 (mean±SD) for salbutamol and placebo (P = .06), respectively, while leg oxygen consumption was around two-fold higher (P < .01) for salbutamol than for placebo (25±3 vs 14±1 mL×min-1). No treatment differences were observed in leg glucose uptake, lactate release, and oxygen consumption during exercise. But in recovery, cumulated leg glucose uptake, lactate release, and oxygen consumption was 21 mmol (95% CI: 18-24, P = .018), 19 mmol (95%CI: 16-23, P < .01), and 1.8 L (95% CI: 1.6-2.0, P < .01) higher for salbutamol than for placebo, respectively. Muscle glycogen content was around 30% lower (P < .01) for salbutamol than for placebo in recovery, whereas no treatment differences were observed in muscle glycogen resynthesis or glycogen synthase activity.Conclusions: Exercise blunts the effect of beta2-agonist on leg glucose uptake, but this attenuation diminishes in recovery. Beta2-agonist increases leg lactate release in recovery, which may relate to glycolytic trafficking due to excessive myocellular glucose uptake.",
keywords = "Faculty of Science, Thermogenesis, Adrenoceptor, Glycogenolysis, cAMP, PKA, Beta-agonist, Clenbuterol",
author = "Johan Onslev and Martin Thomassen and J{\o}rgen Wojtaszewski and Jens Bangsbo and Morten Hostrup",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1210/clinem/dgab752",
language = "English",
volume = "107",
pages = "e1193--e1203",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from exercise

AU - Onslev, Johan

AU - Thomassen, Martin

AU - Wojtaszewski, Jørgen

AU - Bangsbo, Jens

AU - Hostrup, Morten

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Content: Exercise blunts the effect of beta2-agonist on peripheral glucose uptake and energy expenditure. Whether such attenuation extends into recovery is unknown.Objective: To examine the effect of beta2-agonist on leg glucose uptake and metabolic rate in recovery from exercise.Design: Using leg arteriovenous balance technique and analyses of thigh muscle biopsies, we investigated the effect of beta2-agonist (24 mg oral salbutamol) vs placebo on leg glucose, lactate, and oxygen exchange before, during, and 0.5-5-h in recovery from quadriceps exercise, as well as on muscle glycogen resynthesis and activity in recovery. Twelve healthy, lean young men participated.Results: Before exercise, leg glucose uptake was 0.42±0.12 and 0.20±0.02 mmol×min-1 (mean±SD) for salbutamol and placebo (P = .06), respectively, while leg oxygen consumption was around two-fold higher (P < .01) for salbutamol than for placebo (25±3 vs 14±1 mL×min-1). No treatment differences were observed in leg glucose uptake, lactate release, and oxygen consumption during exercise. But in recovery, cumulated leg glucose uptake, lactate release, and oxygen consumption was 21 mmol (95% CI: 18-24, P = .018), 19 mmol (95%CI: 16-23, P < .01), and 1.8 L (95% CI: 1.6-2.0, P < .01) higher for salbutamol than for placebo, respectively. Muscle glycogen content was around 30% lower (P < .01) for salbutamol than for placebo in recovery, whereas no treatment differences were observed in muscle glycogen resynthesis or glycogen synthase activity.Conclusions: Exercise blunts the effect of beta2-agonist on leg glucose uptake, but this attenuation diminishes in recovery. Beta2-agonist increases leg lactate release in recovery, which may relate to glycolytic trafficking due to excessive myocellular glucose uptake.

AB - Content: Exercise blunts the effect of beta2-agonist on peripheral glucose uptake and energy expenditure. Whether such attenuation extends into recovery is unknown.Objective: To examine the effect of beta2-agonist on leg glucose uptake and metabolic rate in recovery from exercise.Design: Using leg arteriovenous balance technique and analyses of thigh muscle biopsies, we investigated the effect of beta2-agonist (24 mg oral salbutamol) vs placebo on leg glucose, lactate, and oxygen exchange before, during, and 0.5-5-h in recovery from quadriceps exercise, as well as on muscle glycogen resynthesis and activity in recovery. Twelve healthy, lean young men participated.Results: Before exercise, leg glucose uptake was 0.42±0.12 and 0.20±0.02 mmol×min-1 (mean±SD) for salbutamol and placebo (P = .06), respectively, while leg oxygen consumption was around two-fold higher (P < .01) for salbutamol than for placebo (25±3 vs 14±1 mL×min-1). No treatment differences were observed in leg glucose uptake, lactate release, and oxygen consumption during exercise. But in recovery, cumulated leg glucose uptake, lactate release, and oxygen consumption was 21 mmol (95% CI: 18-24, P = .018), 19 mmol (95%CI: 16-23, P < .01), and 1.8 L (95% CI: 1.6-2.0, P < .01) higher for salbutamol than for placebo, respectively. Muscle glycogen content was around 30% lower (P < .01) for salbutamol than for placebo in recovery, whereas no treatment differences were observed in muscle glycogen resynthesis or glycogen synthase activity.Conclusions: Exercise blunts the effect of beta2-agonist on leg glucose uptake, but this attenuation diminishes in recovery. Beta2-agonist increases leg lactate release in recovery, which may relate to glycolytic trafficking due to excessive myocellular glucose uptake.

KW - Faculty of Science

KW - Thermogenesis

KW - Adrenoceptor

KW - Glycogenolysis

KW - cAMP

KW - PKA

KW - Beta-agonist

KW - Clenbuterol

U2 - 10.1210/clinem/dgab752

DO - 10.1210/clinem/dgab752

M3 - Journal article

C2 - 34665856

VL - 107

SP - e1193-e1203

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

ID: 282531877