Factors mediating exercise-induced organ crosstalk

Research output: Contribution to journal › Review › Research › peer-review

Standard

Factors mediating exercise-induced organ crosstalk. / Sabaratnam, Rugivan; Wojtaszewski, Jørgen; Højlund, Kurt.

In: Acta Physiologica, Vol. 234, No. 2, e13766, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Sabaratnam, R, Wojtaszewski, J & Højlund, K 2022, 'Factors mediating exercise-induced organ crosstalk', Acta Physiologica, vol. 234, no. 2, e13766. https://doi.org/10.1111/apha.13766

APA

Sabaratnam, R., Wojtaszewski, J., & Højlund, K. (2022). Factors mediating exercise-induced organ crosstalk. Acta Physiologica, 234(2), [e13766]. https://doi.org/10.1111/apha.13766

Vancouver

Sabaratnam R, Wojtaszewski J, Højlund K. Factors mediating exercise-induced organ crosstalk. Acta Physiologica. 2022;234(2). e13766. https://doi.org/10.1111/apha.13766

Author

Sabaratnam, Rugivan ; Wojtaszewski, Jørgen ; Højlund, Kurt. / Factors mediating exercise-induced organ crosstalk. In: Acta Physiologica. 2022 ; Vol. 234, No. 2.

Bibtex

@article{5775accdef954b4a999c6ed43ee49948,
title = "Factors mediating exercise-induced organ crosstalk",
abstract = "Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.",
keywords = "Faculty of Science, Exercise, Skeletal muscle, Myokines, Exerkines, Hepatokines, Crosstalk, Exosomes",
author = "Rugivan Sabaratnam and J{\o}rgen Wojtaszewski and Kurt H{\o}jlund",
note = "This article is protected by copyright. All rights reserved.",
year = "2022",
doi = "10.1111/apha.13766",
language = "English",
volume = "234",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Factors mediating exercise-induced organ crosstalk

AU - Sabaratnam, Rugivan

AU - Wojtaszewski, Jørgen

AU - Højlund, Kurt

N1 - This article is protected by copyright. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.

AB - Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.

KW - Faculty of Science

KW - Exercise

KW - Skeletal muscle

KW - Myokines

KW - Exerkines

KW - Hepatokines

KW - Crosstalk

KW - Exosomes

U2 - 10.1111/apha.13766

DO - 10.1111/apha.13766

M3 - Review

C2 - 34981891

VL - 234

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 2

M1 - e13766

ER -

ID: 288854853